HRID1045634
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
CONDITIONS
反应条件
- 温度
- 120 °C
PROCEDURE
实验过程
A suspension of thiourea (620 mg) and 3-bromomethyl-pyrazine-2-carboxylic acid ethyl ester (2 g) in tetrahydrofuran was heated in the microwave at 120° C. for 5 minutes. The product formed an oil so the tetrahydrofuran was simply decanted to leave 3-carbamimidoylsulfanylmethyl-pyrazine-2-carboxylic acid ethyl ester hydrobromide (2.2 g) as an oil. MH+=241, RT=0.26 min (Method A).
WORKUP
后处理
- customwas simply decanted