Potassium Carbonate → HCID 67495477, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(2,3-dichloro-6-fluoro-phenylmethanesulfonylmethyl)-pyrazine-2-carboxylic acid methyl ester (0.261 g) and potassium carbonate (0.182 g) in N,N-dimethylformamide (6 ml) was heated to 100° C. for 2 hours. The reaction mixture was cooled to ambient temperature, diluted with water and washed with diethyl ether. The aqueous layer was acidified with aqueous hydrochloric acid (2M) and the resulting precipitate isolated by filtration. The precipitate was washed with water and diethyl ether and dried to give Compound No. C1 of Table C (0.106 g). MH+=361, RT=1.35 min.

Provenance & Evidence