Potassium Carbonate → HCID 67495477, compound

HRID 1045638Notes

Reaction equation

HRID 1045638 reaction equation
CO[C:3]([C:5]1[C:10]([CH2:11][S:12]([CH2:15][C:16]2[C:21]([F:22])=[CH:20][CH:19]=[C:18]([Cl:23])[C:17]=2[Cl:24])(=[O:14])=[O:13])=[N:9][CH:8]=[CH:7][N:6]=1)=[O:4].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[Cl:24][C:17]1[C:18]([Cl:23])=[CH:19][CH:20]=[C:21]([F:22])[C:16]=1[C:15]1[S:12](=[O:14])(=[O:13])[CH2:11][C:10]2[N:9]=[CH:8][CH:7]=[N:6][C:5]=2[C:3]=1[OH:4]

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 66788914HCID 66788914, compound

Product 1

HCID 67495477HCID 67495477, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 3-(2,3-dichloro-6-fluoro-phenylmethanesulfonylmethyl)-pyrazine-2-carboxylic acid methyl ester (0.261 g) and potassium carbonate (0.182 g) in N,N-dimethylformamide (6 ml) was heated to 100° C. for 2 hours. The reaction mixture was cooled to ambient temperature, diluted with water and washed with diethyl ether. The aqueous layer was acidified with aqueous hydrochloric acid (2M) and the resulting precipitate isolated by filtration. The precipitate was washed with water and diethyl ether and dried to give Compound No. C1 of Table C (0.106 g). MH+=361, RT=1.35 min.

Workup

  1. temperatureThe reaction mixture was cooled to ambient temperature
  2. washwashed with diethyl ether
  3. customthe resulting precipitate isolated by filtration
  4. washThe precipitate was washed with water and diethyl ether
  5. customdried
  6. customto give Compound No

Sources & evidence

ORD record
ord-3a82fce01f39496facb400b20d4dbe21
Source dataset
uspto-grants-2013_10
Patent number
US08569301B2

Reaction notes

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