反应详情

Aminoacetaldehyde dimethylacetal (20.05 g, 191 mmol) was added to the solution of 2-chloro-N-phenethyl-acetamide (18.33 g, 92.7 mmol) in toluene (92 ml) and refluxed in 2 hours. After ice-cooling and removal of precipitate by filtration, filtrate was washed with water and dried with magnesium sulfate. The solvents were removed under reduced pressure, and 4N hydrogen chloride in ethyl acetate (18 ml) was added to the residue followed by filtration and wash with ethyl acetate and diethyl ether afforded 2-(2,2-dimethoxy-ethylamino)-N-phenethyl-acetamide hydrochloride (8.77 g, 52%).

1. temperaturerefluxed in 2 hours
2. temperatureAfter ice-cooling
3. customremoval of precipitate
4. filtrationby filtration, filtrate
5. washwas washed with water
6. dry with materialdried with magnesium sulfate
7. customThe solvents were removed under reduced pressure, and 4N hydrogen chloride in ethyl acetate (18 ml)
8. additionwas added to the residue
9. filtrationfollowed by filtration
10. washwash with ethyl acetate and diethyl ether