HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 25002827, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 25002828 | HCID 25002828 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 25002827 | HCID 25002827 | 97% |
Reaction Steps
Hydrogen chloride (4N) in ethyl acetate (6 ml) was added to a solution of 3-methyl-2-(3-phenyl-pyrrolidin-1-yl)-6-pyridin-4-yl-3H-pyrimidin-4-one (576 mg, 1.73 mmol) in methanol (3 ml) and the mixture was stirred for 15 minutes. Azeotropic removal of the solvents and excess hydrogen chloride afforded 3-methyl-2-(3-phenyl-pyrrolidin-1-yl)-6-pyridin-4-yl-3H-pyrimidin-4-one hydrochloride (621 mg, 97%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569294B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-d782d46d01ad44ffa74a7133af21361a |
| Source note | uspto-grants-2013_10 |