Hydrochloric Acid → HCID 25002827, compound

HRID 1045681Notes

Reaction equation

HRID 1045681 reaction equation
[ClH:1].[CH3:2][N:3]1[C:8](=[O:9])[CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[N:5]=[C:4]1[N:16]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:17]1>C(OCC)(=O)C.CO>[ClH:1].[CH3:2][N:3]1[C:8](=[O:9])[CH:7]=[C:6]([C:10]2[CH:15]=[CH:14][N:13]=[CH:12][CH:11]=2)[N:5]=[C:4]1[N:16]1[CH2:20][CH2:19][CH:18]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:17]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 25002828HCID 25002828, compound

Product 1

HCID 25002827HCID 25002827, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Hydrogen chloride (4N) in ethyl acetate (6 ml) was added to a solution of 3-methyl-2-(3-phenyl-pyrrolidin-1-yl)-6-pyridin-4-yl-3H-pyrimidin-4-one (576 mg, 1.73 mmol) in methanol (3 ml) and the mixture was stirred for 15 minutes. Azeotropic removal of the solvents and excess hydrogen chloride afforded 3-methyl-2-(3-phenyl-pyrrolidin-1-yl)-6-pyridin-4-yl-3H-pyrimidin-4-one hydrochloride (621 mg, 97%).

Workup

  1. customAzeotropic removal of the solvents and excess hydrogen chloride

Sources & evidence

ORD record
ord-d782d46d01ad44ffa74a7133af21361a
Source dataset
uspto-grants-2013_10
Patent number
US08569294B2

Reaction notes

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