Hydrazine hydrate (1:1) → HCID 58447017, compound

HRID 1045742Notes

Reaction equation

HRID 1045742 reaction equation
[Br:1][C:2]1[C:7]([CH3:8])=[N:6][C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]2)=[C:4](Br)[N:3]=1.O.[NH2:18][NH2:19]>CCO>[Br:1][C:2]1[C:7]([CH3:8])=[N:6][C:5]([N:9]2[CH2:14][CH2:13][N:12]([CH3:15])[CH2:11][CH2:10]2)=[C:4]([NH:18][NH2:19])[N:3]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 58447011HCID 58447011, compound

Product 1

HCID 58447017HCID 58447017, compoundYield 54%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A 100 mL round bottom flask was charged with 2,6-dibromo-3-methyl-5-(4-methylpiperazin-1-yl)pyrazine (2.0 g, 5.7 mmol), hydrazine hydrate (3.5 g, 0.065 mol) and absolute EtOH (30 mL). The resulting solution was refluxed under N2 atmosphere overnight. Work-up: the solvent was evaporated. The residue was washed with EtOH (10 mL) and dried, to afford 0.92 g (54%) of the product as a yellow solid.

Workup

  1. temperatureThe resulting solution was refluxed under N2 atmosphere overnight
  2. customthe solvent was evaporated
  3. washThe residue was washed with EtOH (10 mL)
  4. customdried

Sources & evidence

ORD record
ord-952db87f7bab49848d48a7913c274078
Source dataset
uspto-grants-2013_10
Patent number
US08569300B2

Reaction notes

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