HCID 58447005, compound → HCID 53391362, compound

HRID 1045757Notes

Reaction equation

C(OC([NH:8][C:9]1[N:10]=[C:11]2[C:16]([N:17]3[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]3)=[N:15][CH:14]=[C:13]([C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)[N:12]2[CH:35]=1)=O)(C)(C)C.C(OC(N1CCN(C2C3N(C=C(C(OCC)=O)N=3)C(C3SC=CC=3)=CN=2)CC1)=O)(C)(C)C>>[N:17]1([C:16]2[C:11]3[N:12]([CH:35]=[C:9]([NH2:8])[N:10]=3)[C:13]([C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)=[CH:14][N:15]=2)[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1

Participants

Reactant 2

HCID 58447005HCID 58447005, compound

HCID 58447048HCID 58447048, compound

Product 1

HCID 53391362HCID 53391362, compound

Procedure

The title compound was prepared as described as in Example 61 step 6, except that tert-butyl 4-(2-((tert-butoxycarbonyl)amino)-5-(thiophen-2-yl)imidazo[1,2-a]pyrazin-8-yl)piperazine-1-carboxylate was substituted for ethyl 8-(4-(tert-butoxycarbonyl)piperazin-1-yl)-5-(thiophen-2-yl)imidazo[1,2-a]pyrazine-2-carboxylate. 1H NMR (300 MHz, DMSO-d6) δ: 7.71 (dd, J=5.1, 1.2 Hz, 1H), 7.46 (dd, J=3.6, 1.2 Hz, 1H), 7.40 (s, 1H), 7.22 (dd, J=5.1, 3.6 Hz, 1H), 7.08 (s, 1H), 5.23 (br, 2H), 4.01 (t, J=5.0 Hz, 4H), 2.79 (t, J=5.0 Hz, 4H). MS m/z: 301 (M+H+).

Sources & evidence

ORD record: ord-dbe8085f58ce419a888d7d1de67941ef
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08569300B2

Reaction notes

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