Diisopropylethylamine → HCID 58446994, compound

Participants

Reaction Steps

A 100 mL round bottom flask was charged with 5-bromo-2-chloropyrimidin-4-amine (8.0 g, 40 mmol), N,N-diisopropylethylamine (16.0 g, 120 mmol) and tert-butyl piperazine-1-carboxylate (11.0 g, 60 mmol). The resulting mixture was heated at reflux overnight. Work-up: the solvent was evaporated. The residue was re-crystallized from ethanol to afford 9.0 g (65%) of the product as a white solid. MS m/z: 358 (M+H+).

Provenance & Evidence