Hydrochloric Acid → HCID 58447058, compound

HRID 1045777Notes

Reaction equation

HRID 1045777 reaction equation
[Br:1][C:2]1[C:3]([NH:9][NH2:10])=[N:4][C:5]([Cl:8])=[N:6][CH:7]=1.Cl.[N:12]([O-])=O.[Na+]>O>[Br:1][C:2]1[C:3]2[N:4]([N:12]=[N:10][N:9]=2)[C:5]([Cl:8])=[N:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 23668193Sodium NitriteHCID 584469695-BROMO-2-CHLORO-4-HYDRAZINYLPYRIMIDINE

Product 1

HCID 58447058HCID 58447058, compoundYield 72.1%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
10 °C

Procedure

A 250 mL round bottom flask was charged with 5-bromo-2-chloro-4-hydrazinylpyrimidine (17 g, crude, 59.2 mmol) and 3 M HCl (600 mL). To the above was added dropwise a solution of NaNO2 (8 g, 0.1 mol) in water (15 mL) at 10° C. The resulting mixture was stirred at 10° C. for 1 h. Work-up: the resulting crystalline solid was collected by filtration. The solid was washed with ethanol (20 mL), and dried to afford 10 g (72%) of the product as a red solid.

Workup

  1. filtrationthe resulting crystalline solid was collected by filtration
  2. washThe solid was washed with ethanol (20 mL)
  3. customdried

Sources & evidence

ORD record
ord-fc4509393b9145a49d03fc8ba30a5fca
Source dataset
uspto-grants-2013_10
Patent number
US08569300B2

Reaction notes

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