Methyl 3-chloro-2-oxopropanoate → 2-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

HRID 1045866Notes

Reaction equation

HRID 1045866 reaction equation
[CH3:1][O:2][C:3](=[O:8])[C:4](=O)[CH2:5]Cl.[N+:9]([C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:20]=1[NH:19][C:18]([C:21](=[S:23])[NH2:22])=[CH:17]2)([O-:11])=[O:10]>>[CH3:1][O:2][C:3]([C:4]1[N:22]=[C:21]([C:18]2[NH:19][C:20]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][C:12]=3[N+:9]([O-:11])=[O:10])[S:23][CH:5]=1)=[O:8]

Participants

3

Reactant 2

HCID 12530121Methyl 3-chloro-2-oxopropanoateHCID 579018667-nitro-1H-indole-2-carbothioamide

Product 1

HCID 1363372002-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

Procedure

3-Chloro-2-oxo-propionic acid methyl ester and 7-nitro-1H-indole-2-carbothioic acid amide prepared in Step A of Preparation 110 were reacted according to the same procedure as Preparation 110 to give the title compound.

Workup

  1. customwere reacted
  2. customaccording to the same procedure as Preparation 110

Sources & evidence

ORD record
ord-e5b63f360e7a4bf096747d2247f42503
Source dataset
uspto-grants-2013_10
Patent number
US08569307B2

Reaction notes

Loading…