HCID 50896569, compound → HCID 58336597, compound

HRID 1045967Notes

Reaction equation

HRID 1045967 reaction equation
Cl[C:2]1[CH:7]=[C:6]([NH:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:18]=2[C:17](=[O:19])[N:16]([CH3:20])[CH2:15][CH2:14]3)[C:5]([Cl:21])=[CH:4][N:3]=1.[F:22][CH:23]([F:31])[N:24]1[CH:28]=[C:27]([NH2:29])[C:26]([CH3:30])=[N:25]1>>[Cl:21][C:5]1[C:6]([NH:8][C:9]2[CH:10]=[CH:11][CH:12]=[C:13]3[C:18]=2[C:17](=[O:19])[N:16]([CH3:20])[CH2:15][CH2:14]3)=[CH:7][C:2]([NH:29][C:27]2[C:26]([CH3:30])=[N:25][N:24]([CH:23]([F:31])[F:22])[CH:28]=2)=[N:3][CH:4]=1

Participants

3

Reactant 2

HCID 50896569HCID 50896569, compoundHCID 866551378-[(2,5-Dichloropyridin-4-yl)amino]-2-methyl-3,4-dihydroisoquinolin-1-one

Product 1

HCID 58336597HCID 58336597, compound

Procedure

This compound was prepared from 8-[(2,5-dichloropyridin-4-yl)amino]-2-methyl-3,4-dihydroisoquinolin-1-one and 1-(difluoromethyl)-3-methyl-pyrazol-4-amine. Column chromatography (SiO2, 50 equiv.; 50:50; EtOAc:MeOH) followed by re-crystallisation from warm MeOH (1-2 mL) furnished 64 mg of the desired product.

Workup

  1. customColumn chromatography (SiO2, 50 equiv.; 50:50; EtOAc:MeOH) followed by re-crystallisation
  2. temperaturefrom warm MeOH (1-2 mL)

Sources & evidence

ORD record
ord-e96dee3d8bcf462ebbed3252c41989a9
Source dataset
uspto-grants-2013_10
Patent number
US08569298B2

Reaction notes

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