HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 50896569, compound → HCID 58336597, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 50896569 | HCID 50896569 | — |
| Reactant | 8-[(2,5-Dichloropyridin-4-yl)amino]-2-methyl-3,4-dihydroisoquinolin-1-one | HCID 86655137 | — |
| Product | HCID 58336597 | HCID 58336597 | — |
Reaction Steps
This compound was prepared from 8-[(2,5-dichloropyridin-4-yl)amino]-2-methyl-3,4-dihydroisoquinolin-1-one and 1-(difluoromethyl)-3-methyl-pyrazol-4-amine. Column chromatography (SiO2, 50 equiv.; 50:50; EtOAc:MeOH) followed by re-crystallisation from warm MeOH (1-2 mL) furnished 64 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569298B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-e96dee3d8bcf462ebbed3252c41989a9 |
| Source note | uspto-grants-2013_10 |