反应详情

温度

60 °C

A mixture of ethyl 5-(4-fluorophenyl)-4-oxo-1,4-dihydropyridine-3-carboxylate (1.5 g, 5.7 mmol) and iodomethane (0.9 g, 6.3 mmol) in saturated NaHCO3 (25 mL) was stirred at 60° C. overnight. The mixture was filtered. The solid was concentrated under vacuum to afford ethyl 5-(4-fluorophenyl)-1-methyl-4-oxo-1,4-dihydropyridine-3-carboxylate (1.1 g, 69.9% yield). The mixture was used directly without further purification.

1. filtrationThe mixture was filtered
2. concentrationThe solid was concentrated under vacuum