Ethanol → Lamivudine

Participants

Reaction Steps

To 1000 ml of ethanol was added 120 g of Lamivudine oxalate (prepared by the method of the present invention). 60 ml of triethylamine was added thereto at the temperature of 40˜45° C. for 0.5 hour, and stirred at the same temperature for 4 hours. The mixture was centrifuged at room temperature and dried under vacuum at the temperature of 40˜45° C. to obtain Lamivudine crystal.

Provenance & Evidence