反应详情

A solution of benzyl 2-aminoethylcarbamate hydrochloride (4.33 g, 18.8 mmol), N-[2-(diisopropylamino)ethyl]-1H-imidazole-1-carboxamide (Preparation 19) (3.73 g, 15.64 mmol) and triethylamine (2.62 ml, 18.8 mmol) in dichloromethane (100 ml) was heated under reflux for 14 hours. The solution was allowed to cool to room temperature and then washed with water (20 ml). The aqueous layer was separated and extracted with more dichloromethane (20 ml). The combined organic layers were dried over anhydrous magnesium sulfate and solvent evaporated under reduced pressure to give the title compound as a yellow oil (6.25 g).

1. temperatureunder reflux for 14 hours
2. washwashed with water (20 ml)
3. customThe aqueous layer was separated
4. extractionextracted with more dichloromethane (20 ml)
5. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate and solvent
6. customevaporated under reduced pressure