反应详情

温度

100 °C

To a solution of 400 mg (2.18 mmol) [2-(2-methoxy-ethoxy)-pyridin-3-yl]-methanol in 4 ml dioxane at r.t. is added 1.12 ml (6.55 mmol) Hünig's base followed by 170 μl (2.18 mmol) mesyl chloride and the mixture is stirred for 5 min. 641 mg (2.18 mmol) (2-amino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone is added to this mixture with the addition of 1 ml of dioxane. The reaction mixture is then heated to 100° C. and stirred overnight. The mixture is partitioned between ether/water and the organic layer is washed with brine, dried with Na2SO4, filtered and evaporated. Flash-chromatography (ethyl acetate/ether 1:1) yields a yellow oil

1. stirringstirred overnight
2. customThe mixture is partitioned between ether/water
3. washthe organic layer is washed with brine
4. dry with materialdried with Na2SO4
5. filtrationfiltered
6. customevaporated
7. customFlash-chromatography (ethyl acetate/ether 1:1) yields a yellow oil