Sodium Hydroxide → 5-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one

HRID 1046385Notes

Reaction equation

HRID 1046385 reaction equation
[CH2:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]([NH:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:5]=1[C:19]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=1)=O)[CH:2]=[CH2:3].[O-:30][C:31]#[N:32].[Na+].[OH-].[Na+]>C(O)(=O)C>[CH2:1]([C:4]1[C:9]([OH:10])=[CH:8][CH:7]=[C:6]2[C:5]=1[C:19]([C:21]1[CH:26]=[CH:25][C:24]([CH:27]([CH3:29])[CH3:28])=[CH:23][CH:22]=1)=[N:32][C:31](=[O:30])[N:11]2[CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 14798Sodium HydroxideHCID 517096Sodium CyanateHCID 45141177(2-Allyl-6-benzylamino-3-hydroxy-phenyl)-(4-isopropyl-phenyl)-methanone

Product 1

HCID 451413895-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 15 mg (39 μmol) (2-allyl-6-benzylamino-3-hydroxy-phenyl)-(4-isopropyl-phenyl)-methanone and 2.5 mg sodium cyanate in 0.2 ml acetic acid is stirred at r.t. for 16 h. Aqueous sodium hydroxide solution is added and the product is extracted with dichloromethane.

Workup

  1. extractionthe product is extracted with dichloromethane

Sources & evidence

ORD record
ord-3d54781c3b294333a72022c33f975404
Source dataset
uspto-grants-2013_10
Patent number
US08569317B2

Reaction notes

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