HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 5-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium Cyanate | HCID 517096 | — |
| Reactant | (2-Allyl-6-benzylamino-3-hydroxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 45141177 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 5-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-1H-quinazolin-2-one | HCID 45141389 | — |
Reaction Steps
A solution of 15 mg (39 μmol) (2-allyl-6-benzylamino-3-hydroxy-phenyl)-(4-isopropyl-phenyl)-methanone and 2.5 mg sodium cyanate in 0.2 ml acetic acid is stirred at r.t. for 16 h. Aqueous sodium hydroxide solution is added and the product is extracted with dichloromethane.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569317B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-3d54781c3b294333a72022c33f975404 |
| Source note | uspto-grants-2013_10 |