反应详情

温度

0 °C

A solution of 2-[3-(2-methylsulfanyl-pyrimidin-4-yl)-imidazo[1,2-a]pyridin-8-yl]-propan-2-ol (0.5 g) in DCM (100 mL) was cooled to 0° C., and MCPBA (0.376 g) was added. The reaction mixture was stirred at 0° C. for 2 h, then quenched with 10% Na2S2O3 (aq). The organic layer was washed with NaHCO3 (sat'd aq), separated, and dried over Na2SO4, filtered, concentrated, and titurated with EtOAc and filtered to provide 2-[3-(2-methylsulfinyl-pyrimidin-4-yl)-imidazo[1,2-a]pyridin-8-yl]-propan-2-ol (0.4 g).

1. customquenched with 10% Na2S2O3 (aq)
2. washThe organic layer was washed with NaHCO3 (sat'd aq)
3. customseparated
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. filtrationfiltered