(Pyridin-4-yl)boronic acid → HCID 67503588, compound

HRID 1047092Notes

Reaction equation

HRID 1047092 reaction equation
Br[C:2]1[N:3]=[C:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[NH:8][C:7]3[N:15]=[CH:16][CH:17]=[CH:18][C:6]=3[N:5]2[C:19]=1[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[N:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][CH:27]=1>>[C:20]1([C:19]2[N:5]3[C:6]4[CH:18]=[CH:17][CH:16]=[N:15][C:7]=4[NH:8][C:9]4[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=4[C:4]3=[N:3][C:2]=2[C:29]2[CH:30]=[CH:31][N:26]=[CH:27][CH:28]=2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 2734379(Pyridin-4-yl)boronic acidHCID 136390213HCID 136390213, compound

Product 1

HCID 67503588HCID 67503588, compound

Procedure

The title compound was synthesized according to the procedure described in step 1 of example 19 using 2-bromo-3-phenyl-9H-benzo[f]imidazo[1,2-d]pyrido[2,3-b][1,4]diazepine and pyridin-4-ylboronic acid. 1HNMR (CDCl3) 400 MHz δ: 8.50-8.47 (m, 2H), 8.18-8.14 (m, 1H), 8.06-8.03 (m, 1H), 7.49-7.46 (m, 2H), 7.44-7.31 (m, 5H), 7.29-7.22 (m, 1H), 7.20-7.16 (m, 1H), 6.98-6.94 (m, 1H), 6.83-6.78 (m, 1H), 6.64 (dd, J=8.0, 4.6 Hz, 1H), 6.28 (br s, 1H); LC/MS: 388 [M+H].

Sources & evidence

ORD record
ord-0aa2dd444a984e118df877c9ece108b5
Source dataset
uspto-grants-2013_10
Patent number
US08569331B2

Reaction notes

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