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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1047105Generated: November 2, 2026

Sodium borohydride → (1S,3S)-6-chloro-3-phenylindan-1-ol

https://huagongshe.com/reaction/1047105

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium borohydrideHCID 4311764—
Reactant(S)-6-chloro-3-phenylindan-1-oneHCID 11997855—
SolventEthanolHCID 702—
Product(1S,3S)-6-chloro-3-phenylindan-1-olHCID 11521607—

Reaction Steps

(S)-6-chloro-3-phenylindan-1-one (IVa) can by reduced with sodium borohydride adapting a method described in Bøgesø J. Med. Chem. 1983, 26, 935, using ethanol as solvent and performing the reaction at approximately 0° C., giving compound (Va).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08569499B2
Source datasetuspto-grants-2013_10
ORD IDord-0145b28b11784be9959ff0effa40ca49
Source noteuspto-grants-2013_10