反应详情

温度

80 °C

The above crude compound ethyl (2Z)-2-[(5-bromo-2-chloropyridin-3-yl)carbonyl]-3-(ethylamino)prop-2-enoate (Intermediate 14, 700 mg) was suspended in acetonitrile (30 mL) and potassium carbonate (0.9 g, 6.53 mmol) and ethylamine (1 eq) were added. The mixture was heated to 80° C. for 16 h then cooled to room temperature and filtered to remove potassium carbonate. Water was added to the filtrate and the precipitated product was filtered and dried to afford 500 mg, 50% of ethyl 6-bromo-1-ethyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate.

1. temperaturethen cooled to room temperature
2. filtrationfiltered
3. customto remove potassium carbonate
4. additionWater was added to the filtrate
5. filtrationthe precipitated product was filtered
6. customdried