HRID1047234

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID78623

N,N-Dimethylformamide dineopentyl acetal

C13H29NO2

结构：CO[C@H]1CC[C@H](CN2C(=O)CNc3ncc(-c4cnc(C(N)=O)cc4C)nc32)CC1

HCID178496567

未命名化合物

PRODUCTS

生成物

$结构：CO[C@H]1CC[C@H](CN2C(=O)CNc3ncc(-c4cnc(C(=O)/N=C\N(C)C)cc4C)nc32)CC1$

HCID178496568

未命名化合物

收率 100%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

CONDITIONS

反应条件

温度: 85 °C

PROCEDURE

实验过程

5-(8-(((trans)-4-Methoxycyclohexyl)methyl)-7-oxo-5,6,7,8-tetrahydropyrazino[2,3-b]pyrazin-2-yl)-4-methylpicolinamide (0.412 g, 1.00 mmol), dimethylformamide dineopentylacetal (1.5 mL) and tetrahydrofuran (10 mL) were combined and heated at 85° C. for 3 h. Reaction was concentrated under a stream of nitrogen placed in reaction vessel. Crude product was used directly for next step (0.467 g, 1.00 mmol, 100% yield). MS (ESI) m/z 466.6 [M+1]+.

WORKUP

后处理

customReaction
concentrationwas concentrated under a stream of nitrogen
customplaced in reaction vessel