4-tert-Butylcyclohexanone → Morpholine, 4-[4-(1,1-dimethylethyl)-1-cyclohexen-1-yl]-

HRID 1047350Notes

Reaction equation

HRID 1047350 reaction equation
[C:1]1([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]=1.[C:13](C1CCC(=O)CC1)([CH3:16])([CH3:15])[CH3:14].N1CCOCC1>C1CCCCC1>[C:13]([CH:4]1[CH2:5][CH2:6][C:1]([N:7]2[CH2:12][CH2:11][O:10][CH2:9][CH2:8]2)=[CH:2][CH2:3]1)([CH3:16])([CH3:15])[CH3:14]

Participants

5

Reactant 3

HCID 73924-tert-ButylcyclohexanoneHCID 8083MorpholineHCID 69589Morpholine, 4-(1-cyclohexen-1-yl)-

Product 1

HCID 11356517Morpholine, 4-[4-(1,1-dimethylethyl)-1-cyclohexen-1-yl]-

Reagents, catalysts & solvents 1

HCID 8078CyclohexaneSolvent

Procedure

Compound III′ (white solid) is obtained quantitatively according to Example 1, from 4-tert-butylcyclohexanone (77.12 g, 0.50 mol), morpholine (54.01 g, 0.62 mol) and cyclohexane (60 mL).

Sources & evidence

ORD record
ord-cc591e3d936c49819385ad7a920d4d27
Source dataset
uspto-grants-2013_10
Patent number
US08569518B2

Reaction notes

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