反应详情

To a solution of ethyl 4-chloro-2-(trifluoromethyl)pyrimidine-5-carboxylate (30.2 g, 119.0 mmol) in ethanol (594 mL) under nitrogen were added palladium (10% on carbon, 50% water wet; 2.58 g, 1.21 mmol) and diisopropylethylamine (50.0 mL, 286.0 mmol). The mixture stirred under hydrogen (1 atm). After 6 h, the mixture was filtered with Celite. The filtrate was concentrated and ethyl acetate was added. The mixture was washed with saturated aqueous sodium bicarbonate (2×), saturated aqueous sodium chloride, dried over sodium sulfate, filtered and concentrated to give the title compound (25.6 g). MS 221.1 (M+1).

1. filtrationthe mixture was filtered with Celite
2. concentrationThe filtrate was concentrated
3. additionethyl acetate was added
4. washThe mixture was washed with saturated aqueous sodium bicarbonate (2×), saturated aqueous sodium chloride
5. dry with materialdried over sodium sulfate
6. filtrationfiltered
7. concentrationconcentrated