Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | ethyl 3-(2,4-difluorophenyl)-1-(3-hydroxybutan-2-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate | HCID 66661487 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Sodium Chloride | HCID 5234 | 879.8% |
| Product | 3-(2,4-Difluorophenyl)-1-(3-hydroxybutan-2-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylic acid | HCID 66661231 | — |
Reaction Steps
To a solution of ethyl 3-(2,4-difluorophenyl)-1-(3-hydroxybutan-2-yl)-1H-thieno[2,3-c]pyrazole-5-carboxylate (134 mg, 0.352 mmol) in methanol (3.5 mL) was added sodium hydroxide (1 M, 1.06 mL, 1.06 mmol). The mixture was stirred at 50° C. for 18 hr. Hydrochloric acid (6M, 0.176 mL, 1.06 mmol) was added. The mixture was concentrated to give the title compound with three equivalents of sodium chloride (181 mg): LC-MS [M+1]=353.3.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08569512B2 |
|---|
| Source dataset | uspto-grants-2013_10 |
|---|
| ORD ID | ord-75e86987a5fa4a0eb980af4c51fd45a3 |
|---|
| Source note | uspto-grants-2013_10 |
|---|
