反应详情

A 200 mL round bottom flask is charged with indan-2,2-dicarboxylic acid tent-butyl ester ethyl ester (8.69 g, 29.93 mmol). DCM (40 mL) and a stirring bar are added. Stirring is initiated. Trifluoroacetic acid (20.0 mL, 269 mmol) is added. After 20 h, tlc analysis (silica, 1:1 ethyl actetate:heptanes), indicates complete consumption of starting material. The reaction mixture is diluted with DCM (50 mL) and evaporated under reduced pressure. The resultant oil is diluted with DCM (55 mL) and evaporated under reduced pressure. The resultant oil is diluted with toluene (50 mL) and evaporated under reduced pressure by pumping to constant weight to give 6.78 g of white solid material.

1. customconsumption of starting material
2. additionThe reaction mixture is diluted with DCM (50 mL)
3. customevaporated under reduced pressure
4. additionThe resultant oil is diluted with DCM (55 mL)
5. customevaporated under reduced pressure
6. additionThe resultant oil is diluted with toluene (50 mL)
7. customevaporated under reduced pressure