HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-[(1,2,3,4-Tetrahydro-isoquinoline-8-carbonyl)-amino]-indan-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 8-(2-Carboxy-indan-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester | HCID 59314104 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | 2-[(1,2,3,4-Tetrahydro-isoquinoline-8-carbonyl)-amino]-indan-2-carboxylic acid | HCID 59314130 | 100% |
Reaction Steps
To a solution of 8-(2-carboxy-indan-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (226) (128 mg, 0.29 mmol) in 6 ml dioxane is added dropwise 4N solution of HCl in dioxane/water (0.72 mL) and the resulting solution is stirred at RT for 4 h. The concentration gave an HCl salt of (219) as white solid (246 mg, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569535B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-bc16ce2077e244c7b6f7d66a737ebef5 |
| Source note | uspto-grants-2013_10 |