反应详情

To a solution of 8-(2-carboxy-indan-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (226) (128 mg, 0.29 mmol) in 6 ml dioxane is added dropwise 4N solution of HCl in dioxane/water (0.72 mL) and the resulting solution is stirred at RT for 4 h. The concentration gave an HCl salt of (219) as white solid (246 mg, 100%).

1. concentrationThe concentration