反应详情

To a solution of 2-(2-Iodo-3-methyl-benzoylamino)-indan-2-carboxylic acid ethyl ester (400 mg, 0.89 mmol) and 3-methoxy-1-propenylboronic acid (206 mg, 1.78 mmol) in 10 mL EtOH/10 mL dioxane is added palladium anchored homogeneous catalyst, FibreCatPd(0), (4.84% Pd, 195 mg, 0.089 mmol) and 2M aqueous solution of K2SO4 (1.78 mL, 3.56 mmol). The resulting reaction mixture is covered with argon and run in a microwave reaction: 110° C., 4 h. After concentration in vacuo, the residue is purified by HPLC to give the product (220) as pale yellow oil.

1. customThe resulting reaction mixture
2. customrun in a microwave reaction
3. custom110° C., 4 h
4. concentrationAfter concentration in vacuo
5. customthe residue is purified by HPLC