反应详情

A 100 mL flask containing 5-bromo-2-cyclobutoxy-3-methyl-benzoic acid methyl ester (2.07 g, 7.25 mmol) as prepared above is charged with 1,4-dioxane (12 mL) and MeOH (12 mL). A stirring bar is added and stirring is initiated. After dissolution, water (6 mL) is added followed by the LiOH (768 mg, 18.3 μmol). After 18 h, tlc analysis (silica, 10% MeOH/DCM) indicates that the starting material is completely consumed. The pH of the reaction mixture is carefully adjusted to pH 2 by slowly adding dilute aqueous HCl (3%, ˜11 mL). The contents of the flask are poured into a separatory funnel which contains EtOAc (50 mL). The layers are separated. The aqueous layer is extracted with EtOAc (40 mL). The combined organic phases are washed with water (40 mL) and brine (40 mL), dried over MgSO4, filtered and concentrated by pumping to constant weight to give a white solid (1.82 g, 88%).

1. customas prepared
2. additionA stirring bar is added
3. additionis added
4. customis completely consumed
5. additionby slowly adding dilute aqueous HCl (3%, ˜11 mL)
6. additionThe contents of the flask are poured into a separatory funnel which
7. customThe layers are separated
8. extractionThe aqueous layer is extracted with EtOAc (40 mL)
9. washThe combined organic phases are washed with water (40 mL) and brine (40 mL)
10. dry with materialdried over MgSO4
11. filtrationfiltered
12. concentrationconcentrated