3,6-Difluorophthalic acid → 2-Amino-4,7-difluoro-indan-2-carboxylic acid ethyl ester HCl salt

HRID 1047953Notes

Reaction equation

HRID 1047953 reaction equation
[F:1][C:2]1[CH:10]=[CH:9][C:8]([F:11])=[C:4]([C:5](O)=O)[C:3]=1[C:12](O)=O.[ClH:15].[CH2:16]([O:18][C:19]([C:21]1([NH2:32])CC2C(=CC=C(F)C=2F)C1)=[O:20])[CH3:17]>>[ClH:15].[CH2:16]([O:18][C:19]([C:21]1([NH2:32])[CH2:5][C:4]2[C:3](=[C:2]([F:1])[CH:10]=[CH:9][C:8]=2[F:11])[CH2:12]1)=[O:20])[CH3:17]

Participants

3

Reactant 2

HCID 6433853,6-Difluorophthalic acidHCID 685896422-amino-4,5-difluoro-indan-2-carboxylic acid ethyl ester HCl salt

Product 1

HCID 685909942-Amino-4,7-difluoro-indan-2-carboxylic acid ethyl ester HCl salt

Procedure

2-Amino-4,7-difluoro-indan-2-carboxylic acid ethyl ester HCl salt was prepared from 3,6-difluoro-phthalic acid as indicated by the scheme above regarding A7-D7 utilizing the same procedures as for the synthesis of 2-amino-4,5-difluoro-indan-2-carboxylic acid ethyl ester HCl salt.

Sources & evidence

ORD record
ord-316a2a5446b74a879cbd8e1e5eac5830
Source dataset
uspto-grants-2013_10
Patent number
US08569535B2

Reaction notes

Loading…