反应详情

To a solution of (Z)-4-(3-chlorophenyl)but-3-en-1-amine (1.80 g, 9.91 mmol) in methanol (30 mL) was added platinum(IV) oxide (0.18 g, 0.79 mmol), and to the resulting stirred mixture at ambient temperature was fitted a balloon of hydrogen. The flask was purged and refilled five times with hydrogen, and the resulting mixture was stirred at ambient temperature under a balloon of hydrogen for 1 hour. The catalyst was removed by filtration through a glass microfibre filter, and the filtrate was concentrated to afford 4-(3-chlorophenyl)butan-1-amine as a light yellow oil (1.78 g, 98% yield).

1. customThe flask was purged
2. additionrefilled five times with hydrogen
3. stirringthe resulting mixture was stirred at ambient temperature under a balloon of hydrogen for 1 hour
4. customThe catalyst was removed by filtration through a glass microfibre
5. filtrationfilter
6. concentrationthe filtrate was concentrated