Lithium tri-s-butylborohydride → HCID 58573835, compound

HRID 1048522Notes

Reaction equation

HRID 1048522 reaction equation
CCC(C)[BH-](C(C)CC)C(C)CC.[Li+].[Cl:15][C:16]1[CH:17]=[C:18]([C@@H:22]2[C@@H:27]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)[N:26]([C@@H:35]([CH:39]3[CH2:41][CH2:40]3)[C:36](=[O:38])[CH3:37])[C:25](=[O:42])[C@:24]([CH2:44][C:45]([OH:47])=[O:46])([CH3:43])[CH2:23]2)[CH:19]=[CH:20][CH:21]=1>C1COCC1>[Cl:15][C:16]1[CH:17]=[C:18]([C@@H:22]2[C@@H:27]([C:28]3[CH:33]=[CH:32][C:31]([Cl:34])=[CH:30][CH:29]=3)[N:26]([C@@H:35]([CH:39]3[CH2:41][CH2:40]3)[C@@H:36]([OH:38])[CH3:37])[C:25](=[O:42])[C@:24]([CH2:44][C:45]([OH:47])=[O:46])([CH3:43])[CH2:23]2)[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 3611392Lithium tri-s-butylborohydrideHCID 58573925HCID 58573925, compound

Product 1

HCID 58573835HCID 58573835, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

L-Selectride (Aldrich, St. Louis, Mo.), (1M in THF, 5.0 ml, 5.00 mmol) was added dropwise over the course of 5 minutes to a solution of 2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-cyclopropyl-2-oxopropyl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Sources & evidence

ORD record
ord-2267f4a8d5a0411b87fe24eedb50d705
Source dataset
uspto-grants-2013_10
Patent number
US08569341B2

Reaction notes

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