反应详情

温度

100 °C

(S)-tert-leucinol (0.937 g, 7.99 mmol) and (3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one (1 g, 2.66 mmol; Example 261, Step F) were combined in a reaction flask and heated to 100° C. After 2 d, the reaction mixture was cooled to RT and dissolved in ethyl acetate. The organic phase was washed with 3×10 mL 1N HCl and 1×10 mL brine, dried over MgSO4, filtered and concentrated to afford the title compound.

1. temperaturethe reaction mixture was cooled to RT
2. washThe organic phase was washed with 3×10 mL 1N HCl and 1×10 mL brine
3. dry with materialdried over MgSO4
4. filtrationfiltered
5. concentrationconcentrated