Triphosgene → 1261682-57-8

HRID 1048624Notes

Reaction equation

HRID 1048624 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([NH2:9])[C:4]=1[CH3:10].Cl[C:12](Cl)([O:14]C(=O)OC(Cl)(Cl)Cl)Cl>C1(C)C=CC=CC=1>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([N:9]=[C:12]=[O:14])[C:4]=1[CH3:10]

Participants

4

Reactant 2

HCID 94429TriphosgeneHCID 118048223-Methoxy-2-methylaniline

Product 1

HCID 602087991261682-57-8Yield 95.3%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 1-methoxy-2-methyl-3-aminobenzene 15.0 g, triphosgene 48.7 g and toluene 350 mL was stirred with heating under reflux for three hours. The reaction mixtures after standing to cool were concentrated under reduced pressure to give 1-methoxy-3-isocyanato-2-methylbenzene 17.0 g.

Workup

  1. temperaturewith heating
  2. temperatureunder reflux for three hours
  3. temperatureto cool
  4. concentrationwere concentrated under reduced pressure

Sources & evidence

ORD record
ord-39ae8a79eabc4267a2e4c2e2e3e20742
Source dataset
uspto-grants-2016_07
Patent number
US09380782B2

Reaction notes

Loading…