反应详情

温度

60 °C

9 g (0.5 eq) of N-iodosuccinimide at room temperature is added to a solution of 10 g (83 mmol) of 2-hydroxynicotinonitrile in 150 ml of anhydrous dimethylformamide. The reaction mixture is stirred at 60° C. After 30 minutes of stirring, 9 g (0.5 eq) of N-iodosuccinimide is added and then the reaction mixture is stirred at 60° C. for 5 hours. The solvent is evaporated and the precipitate formed is filtered, rinsed with water and with diethyl ether and then dried under vacuum to yield 18.5 g (90%) of 2-hydroxy-5-iodonicotinonitrile in the form of a beige powder.

1. stirringAfter 30 minutes of stirring
2. stirringthe reaction mixture is stirred at 60° C. for 5 hours
3. customThe solvent is evaporated
4. customthe precipitate formed
5. filtrationis filtered
6. washrinsed with water and with diethyl ether
7. customdried under vacuum