反应详情

温度

70 °C

A mixture of 6.5 g of 6-chloro-3-nitropicolinonitrile (0.065 mol) and 6.2 g of 3,5-difluoroaniline (0.048 mol) in 100 ml of toluene is heated at 70° C. for 5 hours. The crude reaction product is diluted in an ethyl acetate fraction and washed using saturated NaCl solution. The organic phase is dried with sodium sulfate and the residue purified by silica gel chromatography (AcOEt/petroleum ether) to yield 3.9 g (33%) of a yellow solid.

1. customThe crude reaction product
2. washwashed
3. dry with materialThe organic phase is dried with sodium sulfate
4. customthe residue purified by silica gel chromatography (AcOEt/petroleum ether)