反应详情

To a solution of monoethyl malonate (0.12 mol) and triethylamine (0.12 mol) acetonitrile (40 mL) and Step-1 intermediate was added (0.02 mol). The mixture was heated to a sufficient temperature to cause considerable evolution of CO2 gas. After 5 h, the solution was concentrated under reduced pressure. The residue was treated with 30% aqueous K2CO3 solution and extracted with diethyl ether, dried over Na2SO4 and concentrated to get the title compound.

1. temperatureThe mixture was heated to a sufficient temperature
2. concentrationthe solution was concentrated under reduced pressure
3. additionThe residue was treated with 30% aqueous K2CO3 solution
4. extractionextracted with diethyl ether
5. dry with materialdried over Na2SO4
6. concentrationconcentrated