反应详情

温度

140 °C

In a 5 mL microwave tube, 2-bromo-5-methyl-1,3,4-oxadiazole (200 mg, 1.23 mmol, Eq: 0.05), Tris(dibenzylideneacetone)dipalladium(0) (56.2 mg, 61.4 μmol, Eq: 0.05) and (R)-(+)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (38.2 mg, 61.4 μmol, Eq: 0.05) were combined with toluene (10.0 ml) to give a brown suspension. Sodium tert-butoxide (236 mg, 2.45 mmol, Eq: 2.00) and 3,5-dichloroaniline (199 mg, 1.23 mmol, Eq: 1.00) were added. The solution was degassed with argon for 5 min, heated to 140° C. for 30 min under microwave.

1. customto give a brown suspension
2. customThe solution was degassed with argon for 5 min