HCID 86696916, compound → 7-(3-Chloropropoxy)-6-methoxyquinolin-4-OL

Temperature

40 °C

0.44 moL of (E)-1-(4-(3-Chloropropoxy)-5-methoxy-2-nitrophenyl)-3-(dimethylamino)prop-2-en-1-one (intermediate IV) (150 g) was dissolved in 1200 mL of glacial acetic acid (8 v/w), and the mixture was heated to 40° C. After intermediate IV was completely dissolve, 2.20 mol (123.1 g) Iron powder was added slowly, then the reaction mixture was heated to 80° C. with mechanical stirring for 2 h. After completion of the reaction, the reaction mixture was filtered immediately to remove iron powder. The filtrate was collected and cooled to precipitate solid, and then filtered to give yellow solid, which was dissolved in glacial acetic acid and the solution was stirred at 80° C. for 30 min then filtered immediately again. The filtrate was cooled to precipitate solid, filtered, and the filter cake was washed with water until the aqueous layer became neutral, dried to give solid 79 g. Yield: 65%.

1. temperaturethe reaction mixture was heated to 80° C.
2. customAfter completion of the reaction
3. filtrationthe reaction mixture was filtered immediately
4. customto remove iron powder
5. customThe filtrate was collected
6. temperaturecooled
7. customto precipitate solid
8. filtrationfiltered
9. customto give yellow solid, which
10. stirringthe solution was stirred at 80° C. for 30 min
11. filtrationthen filtered immediately again
12. temperatureThe filtrate was cooled
13. customto precipitate solid
14. filtrationfiltered
15. washthe filter cake was washed with water until the aqueous layer
16. customdried

ORD record

ord-bb1a1ddfea874552b0d771e987bf5618

Source dataset

uspto-grants-2016_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09382232B2