反应详情

温度

36 °C

A mixture of ethyl 4-isobutyrylbenzoate (0.56 g, 2.54 mmol), hydroxylamine hydrochloride (1.06 g, 15.2 mmol), and sodium acetate (1.25 g, 15.2 mmol) in ethanol (36 mL) was heated to 36° C. for 2 h. The reaction was then concentrated and the residue was dissolved in EtOAc (200 mL). The organic phase was washed with water (2×20 mL), brine, dried (MgSO4), and concentrated to give crude ethyl 4-(1-(hydroxyimino)-2-methylpropyl)benzoate as a slight-yellow solid. LC-MS: (FA) ES+ 236.

1. concentrationThe reaction was then concentrated
2. dissolutionthe residue was dissolved in EtOAc (200 mL)
3. washThe organic phase was washed with water (2×20 mL), brine
4. dry with materialdried (MgSO4)
5. concentrationconcentrated