Iodine → HCID 87410566, compound

HRID 1049122Notes

Reaction equation

HRID 1049122 reaction equation
[CH2:1]([C:3]1[C:16]2[NH:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[S:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)[CH3:2].[I:17]I>C(Cl)(Cl)Cl>[I-:17].[CH2:1]([C:3]1[C:16]2[C:7](=[S+:8][C:9]3[C:14]([N:15]=2)=[CH:13][CH:12]=[CH:11][CH:10]=3)[CH:6]=[CH:5][CH:4]=1)[CH3:2]

Participants

4

Reactant 2

HCID 807IodineHCID 525754610H-Phenothiazine, 1-ethyl-

Product 1

HCID 87410566HCID 87410566, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Conditions

Temperature
0 °C

Procedure

1-Ethyl-10H-phenothiazine (646 mg, 2.84 mmol) was dissolved in CHCl3 (10 mL) and cooled to 0° C. as a solution of Iodine (2.16 g, 8.51 mmol) dissolved in CHCl3 (50 mL) was added dropwise. The mixture was stirred at 0° C. for 2 h, then allowed to warm to RT overnight.

Workup

  1. additionwas added dropwise
  2. temperatureto warm to RT overnight

Sources & evidence

ORD record
ord-c0839109fa6644149ac231e8e11bfdf7
Source dataset
uspto-grants-2016_07
Patent number
US09382221B2

Reaction notes

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