Piperidine → HCID 30042343, compound

HRID 1049222Notes

Reaction equation

HRID 1049222 reaction equation
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:15][CH2:14][N:13]([C:16]([O:18]C3C=CC([N+]([O-])=O)=CC=3)=O)[CH2:12][CH2:11]2)=[CH:6][CH:5]=1)([O-:3])=[O:2].[NH:28]1[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([N:10]2[CH2:11][CH2:12][N:13]([C:16]([N:28]3[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]3)=[O:18])[CH2:14][CH2:15]2)=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 86646745HCID 86646745, compound

Product 1

HCID 30042343HCID 30042343, compoundYield 84.4%

Procedure

Added 0.590 g of 4-nitrophenyl 4-(4-nitrophenyl)piperazine-1-carboxylate to 5.0 mL piperidine and stirred at room temperature until complete. HPLC indicated that reaction was complete after 18 hrs by absence of starting material. Material was added to 15 mL ice water and precipitate formed which was filtered to obtain (4-(4-nitrophenyl)piperazin-1-yl)(piperidin-1-yl)methanone as a yellow powder. Product was allowed to dry under vacuum for 24 hrs (0.426 g, 84.4% yield).

Workup

  1. customHPLC indicated that reaction
  2. customformed which
  3. filtrationwas filtered

Sources & evidence

ORD record
ord-0bcd6c73315a49c5bae5b0f6f896daf0
Source dataset
uspto-grants-2016_07
Patent number
US09382237B2

Reaction notes

Loading…