Pyridine → 2-Nitrobenzamide

HRID 1049227Notes

Reaction equation

HRID 1049227 reaction equation
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6](Cl)=[O:7])([O-:3])=[O:2].[N:13]1C=CC=CC=1>>[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[CH:9][C:5]=1[C:6]([NH2:13])=[O:7])([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 1049PyridineHCID 118752-Nitrobenzoyl chloride

Product 1

HCID 118762-Nitrobenzamide

Conditions

Temperature
90 °C

Procedure

The free amine obtained from the BOC deprotection step was dissolved in pyridine and nitrobenzoyl chloride (1.2 equiv.) was added to this solution. After stirring for 2 h at 90° C., the reaction mixture was concentrated and the resulting crude product was used for the next step without further purification.

Workup

  1. concentrationthe reaction mixture was concentrated
  2. customthe resulting crude product was used for the next step without further purification

Sources & evidence

ORD record
ord-1033424b06c641f18642f42c2da996b8
Source dataset
uspto-grants-2016_07
Patent number
US09382239B2

Reaction notes

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