HCID 117759626, compound → HCID 117759852, compound
Reaction equation
[CH2:1]([O:3][C:4](=[O:15])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][N+:10]([O-])=[C:9]([CH3:14])[CH:8]=1)[CH3:2]>C(OC(=O)C)(=O)C>[C:4]([O:15][CH2:14][C:9]1[CH:8]=[C:7]([CH2:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:15])[CH:12]=[CH:11][N:10]=1)(=[O:3])[CH3:5]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 100 °C
Procedure
A mixture of 4-(3-ethoxy-3-oxopropyl)-2-methylpyridine 1-oxide (1.99 g) and acetic anhydride (10 mL) was stirred at 100° C. for 30 min. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane) to give a crude product of the title compound as a colorless oil. This compound was used for the next step without further purification.
Workup
- customThe solvent was evaporated under reduced pressure
- customthe residue was purified by silica gel column chromatography (NH, ethyl acetate/hexane)
Sources & evidence
- ORD record
- ord-5234278520ea44da8df29208a8ac35aa
- Source dataset
- uspto-grants-2016_07
- Patent number
- US09382188B2
Reaction notes
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