反应详情

温度

50 °C

Under a nitrogen atmosphere, to a solution of (((tert-butyldiphenylsilyl)oxy)methyl)-6-chloropyrimidine (18.6 g) and 1,4-diazabicyclo[2.2.2]octane (8.18 g) in acetonitrile (97 mL) was added tetraethylammonium cyanide (7.59 g) at room temperature, and the mixture was stirred at 50° C. for 30 min. The solvent of the reaction mixture was evaporated under reduced pressure and the insoluble solid was removed by filtration. The solvent of the filtrate was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (11.3 g) as a colorless oil.

1. customThe solvent of the reaction mixture was evaporated under reduced pressure
2. customthe insoluble solid was removed by filtration
3. customThe solvent of the filtrate was evaporated under reduced pressure
4. customthe residue was purified by silica gel column chromatography (ethyl acetate/hexane)