HCID 117760058, compound → HCID 117760038, compound

HRID 1049514Notes

Reaction equation

HRID 1049514 reaction equation
[O:1]1[CH2:6][CH:5]=[C:4]([C:7]2[CH:12]=[C:11]([OH:13])[CH:10]=[CH:9][C:8]=2[C:14]2[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=2[F:22])[CH2:3][CH2:2]1>CO.[C].[Pd]>[F:22][C:15]1[CH:16]=[CH:17][C:18]([O:20][CH3:21])=[CH:19][C:14]=1[C:8]1[CH:9]=[CH:10][C:11]([OH:13])=[CH:12][C:7]=1[CH:4]1[CH2:3][CH2:2][O:1][CH2:6][CH2:5]1

Participants

4

Reactant 1

HCID 117760058HCID 117760058, compound

Product 1

HCID 117760038HCID 117760038, compound

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

To a solution of 2-(3,6-dihydro-2H-pyran-4-yl)-2′-fluoro-5′-methoxybiphenyl-4-ol (138 mg) in methanol (3.0 mL) was added 10% palladium-carbon (55 mg), and the mixture was stirred under a hydrogen atmosphere at room temperature for 1 hr. The mixture was filtered through celite, and the filtrate was concentrated under reduced pressure. The residue was directly used for the next step.

Workup

  1. filtrationThe mixture was filtered through celite
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-d929fcd45c794969b6ed40de91224d9b
Source dataset
uspto-grants-2016_07
Patent number
US09382188B2

Reaction notes

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