反应详情

温度

70 °C

To a solution of 2′-fluoro-2-(1-fluoro-3,3-dimethylbutyl)-5′-methoxy-4-((4-methoxybenzyl)oxy)biphenyl (120 mg) in methanol (5 mL) was added 10% palladium-carbon (100 mg) and, under a hydrogen atmosphere, the mixture was stirred at 70° C. for 17 hr. The reaction mixture was filtered, and the solvent of the filtrate was evaporated under reduced pressure to give a crude product of the title compound as a colorless oil. This compound was used for the next step without further purification.

1. filtrationThe reaction mixture was filtered
2. customthe solvent of the filtrate was evaporated under reduced pressure